- Principal Investigator, Associate Professor
EDUCATION & EXPERIENCE
2007 - present Associate Professor, Shenzhen Graduate School, Peking University
2005 - 2007 Research Scientist, Columbia University and Sloan-Kettering Cancer
2004 - 2005 Ph. D. Columbia University
2000 - 2004 M.Phil. Columbia University
1995 - 1998 M.Sc. Chinese Academy of Sciences
1992 - 1995 B.S. Lanzhou University
New Electronic Helix Theory-guided Rational Design of Asymmetric Catalytic Systems: We recently developed a new electronic helix theory for molecular chiralities and chiral interactions. It shows that complex molecular chiralities can be generalized on the basis of their inherent electronic helicities, and that the fundamental principle underlying chiral induction and recognition is the conservation of helical asymmetry, i.e., a chiral catalyst or host preferentially induces or recognizes chirality of the same helicity. The theory agrees well with all the major experiments reported since the birth of asymmetric synthesis in 1960s, accommodates results that conventional steric theories cannot, and promises predictive power. From a conceptually novel scenario, it reveals that effects in stereochemical control conventionally attributed to steric hindrance instead have an electronic basis. Despite tremendous progress achieved in enantioselective catalysis in the past several decades, endeavors in this frontier field remain largely empirical. The hallmark of our program will therefore keenly focus on demonstrating how this electronic theory could guide design and discovery of broadly useful enantioselective processes from a more rational approach.
Total Synthesis of Bio-active Natural Products: Another particular emphasis of our program is to explore new strategies in total synthesis of natural products that possess considerable stereochemical complexity and significant therapeutic values. The target molecules under our current concern are Longeracinphyllin A, Daphnilongeranin B, and Dapholongamine B.
Discovery and Development of New Pharmaceutical Agents: The Center for Chemical Genomics at Peking University Shenzhen Graduate School has established solid platforms in chemistry, biology, and computation that are essential for modern drug discovery and development. Working closely with colleagues, we are combining our expertise in organic synthesis, high-throughput screening, structural biology, and molecular modeling to design and discover new generation of anti-cancer and anti-viral agents that could help address critical medical needs. One recent focus has been placed on the star natural product Platensimycin.
1. D.Z.Wang, "Conservation of Helical Asymmetry in Chiral Interactions". Tetrahedron, 2005, 61, 7125-7133. For a research highlight, see: Chem & Eng News, 2003, September 29 issue, 34-35.
2.D.Z.Wang, "Catalyst-substrate Helical Character Matching Determines Enantiomeric Excess". Tetrahedron, 2005, 61, 7134-7143.